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Why isn't Mr. Fantastic known as Dr. Fantastic? This just struck me as a little strange. I am sure he has a doctorate.
Dr. Doom, and Dr. strange are happy to advertise theirs. Yet Mr Fantastic is plain old 'Mr'. Is there an in universe explanation or reason for this?
  
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Marvel.com says "Multiple scientific doctorates in fields such as engineering, math and physics from California State Institute of Technology, Columbia University, Harvard and State University, and others" – Izkata Mar 25 '13 at 13:06 
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As a PhD, he doesn't feel the need to have people call him "Doctor", and has said on many occasions that it seems pretentious for anyone other than medical doctors to do so. – John O Mar 25 '13 at 13:15
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@John O - If you can cite some of those occasions, sounds that would be a valid answer to the question. – Stan Mar 25 '13 at 13:18
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He doesn't hold a doctorate in being Fantastic. – Kevin Howell Mar 25 '13 at 14:29
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Dr Doom's name is Victor Von Doom, Dr Strange's name is Stephen Strange, hence Dr Doom and Dr Strange. Mr Fantastic's name is Reed Richards not Reed Fantastic, so he would be Dr Richards. Mr Fantastic is merely his alias. – Ally Morgan Mar 25 '13 at 17:30
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The reason he does not have Dr. Fantastic in his name has to do with his origins at the hands of Jack Kirby and Stan Lee.

According to Stan Lee, “I was utterly determined to have a superhero series without any secret identities. I knew for a fact that if I possessed a super power I’d never keep it secret. I'm too much of a show off. So why should our fictional friends be any different? Accepting this premise, it was also natural to forego the use of costumes. If our heroes were to live in the real world, let them dress like real people.” -- Secret Origins of the Fantastic Four
First images of the Fantastic Four
  • When creating the Fantastic Four, their original premise was they would be Everyman heroes, no secret identities, only codenames. So the day they acquired their powers after the accident, their identities chosen immediately were: Mr. Fantastic, the Invisible Girl, The Human Torch, and the hideous Thing.
  • Stan Lee would only be able to keep his word against costumes because the fans demanded they wear them! By issue three, they were issued their non-uniform uniforms and their codenames were firmly entrenched into history.
  • There was one other reason he remained Mr. Fantastic. The name of his hated arch-enemy, one Dr. Victor Von Doom. Kirby and Lee wanted to be sure to distinguish between the two mentalities of their creations. Richards was allied with the common man, using science to further the opportunities of mankind. Doom only had one ambition, to rule mankind and thus did everything he could to separate him from mankind, making him hideous in appearance, a member of royalty, indeed the ruler of his kingdom of Latveria and a firm belief in his superiority over everyone but especially Reed Richards.
NOTE: Dr. Reed Richards (Mr Fantastic) indeed has multiple degrees in a number of sciences and that number grows every decade. It is safe to say if he needs to know it, he does, and if he doesn't he maintains company with the worlds most famous and capable scientists and inventors including Tony Stark, Dr. Henry Pym, Dr. Henry McCoy, Dr. Charles Xavier (deceased), Dr. Stephen Strange, and even Victor von Doom, (who left school before he could get his doctorate) if the stakes are high enough.
It does sound rather as if those extra degrees Reed has may be honorary, though.  
I suppose Dr. Doom could quite easily get any qualification he wanted from Latveria U, of course. 
And as for "Mr Fantastic's name is Reed Richards not Reed Fantastic, so he would be Dr Richards", I just have to mention Dr. Manhattan. 

Another site says
"Anyone who'd call themselves Fantastic would probably take every opportunity to mention their doctorate(s), too. Hell, he'd probably correct strangers who called him "Mister" Richards. Definitely a dick." 
He has a point.

In fact, now I come to think of it, surgeons don't call themselves doctor, they have quite a thing about being called Mister.  And Stephen Strange was of course a surgeon. 
Not in America. A surgeon is a Doctor of Surgery (DS) as opposed to a Medical Doctor (MD).
And in Australia a doctor isn't a Doctor at all:
Historically, Australian medical schools have followed the British tradition by conferring the degrees of Bachelor of Medicine and Bachelor of Surgery (MBBS) to its graduates whilst reserving the title of Doctor of Medicine (MD) for their researchtraining degree, analogous to the PhD, or for their honorary doctorates.
Really, saying
Kirby and Lee wanted to be sure to distinguish between the two mentalities of their creations. Richards was allied with the common man, using science to further the opportunities of mankind. Doom only had one ambition, to rule mankind and thus did everything he could to separate him from mankind...
does make it rather seem as if using your doctorate is equivalent to declaring war on mankind. Which isn't always the case.