So I have a Basal Cell Carcinoma or two removed, and being a good wikinerd look it up on Wikipedia, and find that
Basal-cell carcinoma also develops as a result of... Gorlin Syndrome.... The cause of the syndrome is a mutation in the PTCH1 tumor-suppressor gene at chromosome 9q22.3, which inhibits the hedgehog signaling pathway. A mutation in the SMO gene, which is also on the hedgehog pathway, also causes basal-cell carcinoma.
Hold it, hold it, where do the hedgehogs come in?
The hedgehog signaling pathway gives cells information that they
need to make the embryo develop properly. Different parts of the embryo
have different concentrations of hedgehog signaling proteins. The
pathway also has roles in the adult. When the pathway malfunctions, it
can result in diseases like basal cell carcinoma.... Mammals have three Hedgehog homologues, of which Sonic hedgehog is the best studied.
At this point I really need to be convinced that someone hasn't been slack about cleaning up after April 1.
Sonic hedgehog homolog (SHH) is one of three proteins in the mammalian signaling pathway family called hedgehog, the others being desert hedgehog (DHH) and Indian hedgehog (IHH). SHH is the best studied ligand of the hedgehog signaling pathway. .... It controls cell division of adult stem cells and has been implicated in development of some cancers.
Well, they've certainly been very thorough.
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